Rejuvenation through vampirism: the medical ethics are not getting easier

For those of you paying attention to either the biomedical literature or to this here blog, it won’t be news that researchers can reverse aging. And it’s easy! At least it is in mice. Just transfuse older rodents with the blood of much younger mice and it’s like that segment of the Twilight Zone movie. The ramifications of this work were obvious and a little queasy*, but it helped that researchers identified a protein called GDF11 that might offer the same benefit in pill or injection form, no young blood required.

Or maybe not.

Egerman [and co-workers] undertook a careful analysis of the function of GDF11 in young and aged mice. They report the opposite of what Sinha et al. reported, that overexpression of GDF11 results in impaired satellite cell function and reduced muscle regeneration. Notably, systemic delivery of GDF11 into old mice had no effect, whereas in young mice muscle regeneration was delayed due to reduced expansion and differentiation of satellite cells.

Meanwhile the overall benefit of perfusing young blood into old rats has held up pretty well.

Ten bucks to be a fly on the wall at Mayhew Insurance while they debate how to cover it.

(*) Count all the people who would prefer not to suffer from old age. Now multiply it by how much young blood each person would need. Factor in just how badly (some) people want to keep their youth and vigor, or get it back. Now consider that the group who wants the blood has all of society’s wealth and influence whereas those who would provide it have none.



Mid-day Open Thread

Yes, most of the polls and the three most reliable poll aggregates show President Obama on track to a 300+ EV victory next Tuesday.

http://polltracker.talkingpointsmemo.com/

http://fivethirtyeight.blogs.nytimes.com/

http://election.princeton.edu/

We’re going to keep the Senate.  Truly, these are good times.  Yay us.  But it’s not over yet. Let’s run the score up on the bastards.

I don’t know shit about phone banking via cell phone, but many of you do.  I know that’s DougJ’s bag, so maybe he’ll post something about it here shortly.  Those of you who do should please put some information down in this thread.

Also, if you haven’t given before, or haven’t given a lot, consider donating a year of double mochachino half-caf lattes to our Act Blue account:

Goal Thermometer

And down-ticket, here’s a link to the PEC High Leverage targets: https://secure.actblue.com/page/pec2012

And last, but absolutely not least, here’s a link to the American Red Cross, where you can donate cash, and not pull a Romney, to disaster relief.  If you can’t afford money for this, donate blood.

 



Be Careful Out There: Vampire Beast-With-Two-Backs Edition

Jumping on the CDC’s Zombie-Apocalypse-Preparedness bandwagon, Planned Parenthood offer some very sage advice:

Let’s face it: vampires can rack up a lot of sexual partners over the years. Your vampire might be the same age as you, or she or he might be thousands of years old. But no matter how old you are, if you’re going to jump into bed with a vampire, you’re going to need more than a clove of garlic to protect your health.

Check the link for the rest of the 411.  My favorite bit:

Vampires might be immortal, but you’re not.

True, dat.

Remember — with vampires, you might be thinking of a night to remember, but for them, it’s always fangs for the mammaries.

(Rimshot, please.)

Happy Hallowe’en, all. (And this should serve as an open thread, no?)

PS: really cool old NSFW in our prudish time pic below the jump.

Read more








Open Thread: Blood Drive

I’m giving blood this morning, and I encourage anyone interested to do so, too.  As usual, in the summer there’s a critical shortage of blood, so give early and often.  This is an open thread.








Blood Drive

It’s blood donation time again for all of us who started giving after Gabby Gifford’s shooting. I’ll be giving this morning, and I hope some of you can find the time to do it.

Speaking of Gabby, she’s had a busy week. On Monday, she saw her husband pilot Endeavour into space. On Wednesday, she had her skull repaired with a ceramic plate and a shunt implanted. Surgery went well, and she’s making good progress in rehab:

Giffords is talking, can understand complicated concepts and is able to recognize subtleties in conversation, including sarcastic humor, Carusone said. She understands when people speak to her in Spanish, Carusone said. Giffords was bilingual before the shooting. Giffords’ voice is the same as it was before the shooting, her staff says.

“She understands, if not everything, close to everything,” Carusone said. “For people who know her, she’s a very determined person.”

She’s still having trouble speaking, and with strength her right side, but all in all, it’s a great recovery so far.








Blood Drive Update

For those of you who participated in the January blood drive, next week will be giving time again, so consider this a gentle reminder. Anyone else interested in giving should check out the Red Cross site for more information.

The reason I started a blood drive was because the Chairman of the Pima County (Tucson) Democratic Party suggested it as a productive response to a Tea Party “Dump Dupnik” protest. Dupnik, you’ll remember, was the Sheriff who served up a few home truths after the killing spree and assassination attempt on Gabrielle Giffords. Since it’s been a couple of months, let’s check in and see how that dump is coming along:

Looks like they need to push a little harder.

But don’t worry, this site will be “updated soon”, perhaps after a few prunes are ingested. Hey, maybe they’ll break some news after breaking wind:

I’ll be giving blood long after the teatards who were butthurt over Dupnik’s truthful statements have moved on to the next nothingburger fauxrage. I hope you’ll join me.



Blood Drive Update

I gave this morning. It was easy and pretty much painless. As I sit here, basking in the self-satisfied feeling of moral superiority that can only be felt by new converts, remember that there’s still a shortage, and in the Rochester, NY area, the Red Cross will give you a coupon for a free pound of Dunkin’ Donuts coffee if you give in January. Here’s the website. Consider this an open thread, as well as an opportunity to sound off if you’ve given recently.