Two important points:
a) Trials pause. All the time. It’s a normal part of good science. It may be nothing. But…
b) Trials fail. All the time. It’s a normal part of good science.
And that’s why no treatment should be overly hyped or promised before making it through trials. https://t.co/lR3FygfjTE
— Daniel Liebman MD MBA (@D_Liebman) October 13, 2020
There are (to use a technical term) a bunch of COVID-19 vaccines and therapeutics working their way through clinical trials. Over the past week, several notable trials have been paused as there have been significant adverse
reactions events that need to be investigated.
THIS IS NORMAL!
We know historically, the funnel from a good idea to promising molecular results to mammalian trials to small scale human trials, to large scale human trials to Phase 3 trials to determine safety and efficacy to final approval has tremendous attrition. Things fail at every point in the process. Things get paused at every stage as weird things happen and need to be investigated to see if these are commonly weird things happening or one in a million events.
And that is okay.
Hell, I would be far more suspicious of the trials pipeline if there have not been stops and restarts. Given the number of vaccine candidates that are past Phase 1, I would, just based on historical record, be shocked if there was not a failure at both Phase 2 and Phase 3. Big failures and little failures are to be expected. Pauses are part of the process.